This will make you have a unstoppable nuke.
First you must be protoss. Then Mind Control A SCV and Drone. To set this up you must have: Ghost (Duh)
Science Vessel - Defence Matrix
Corsair - Destruption Web
Defeiler - Dark Swarm
1. Call a nuke.
2.Put a Destruption Web over the ghost. (Prevents Melee attacks)
3.Put a Dark Swarm Over the ghost. (Prevents Distance attacks)
4.Put a Defence Matrix on the ghost.(Makes minimal Damage Taken)

Now watch you opponent try and stop you. Litterly the only way to stop this is with another nuke. Buuuttt.... by the time he starts his nuke yours is half way finished. :) Have Fun

CreepColony's Opinion: Instead of MCing, you can just have your allies help you, if they are zerg and protoss. Also, have some medics near you ghost. They can optical flare any detectors and heal your ghost if he gets hurt.