This is possibly the most difficult strategy I will ever post. It usually only works if you're facing an idiot or someone who doesn't know why the word 'detector' is on thier Missile Turret, or if you're facing a newbie. If this is the case, time to have some fun.

Step 1: Start the game building lots of defense, but focus on getting the Covert Opps. Get at least 4 Command Centers with armed Nuke Silos.

Step 2: Send about 20 cloaked Ghosts. Tell them to move, not attack. Walk slowly, avoiding detectors if there are any. Find thier main building, whether it be a Command Center, Hive or Nexus. If facing the Zerg, go after the harvesting Hive, not the group of Hatcheries that the units spawn from. Have 2 nukes target the main building, and the rest near the main building where a Factory or something might be. The other Ghosts can attack the outer rim defense, so the enemy will be distracted and not look at there main building.

Step 3: Imagine the screaming of your enemy and read the curses while roaring of laughter.

Difficult to pull off but the results are worth it. lol

CreepColony's Opinion: Defense matrix your ghosts for better results.