Make about 2 ghosts and 6 medics, load em up to a dropship. Make about 4-6 Battle cruisers and 2 science vessels. Get 2 comsats (if you don't already have them) and 2 loaded nuclear silos. Now, scout for the enemies base (don't use comsat). After you have found his/her base scan around the whole base and look where key buildings are crumpled together (eg, for protoss, cybercore, forge, ariber tribune, fleet beacon etc, or where all his/her supply depos/pylons are all in the same area) try to nuke that place. Use the battle cruisers yamato the turrets/cannons/spores that might be in the area and to cover for the ghosts when the ghosts are nuking. Use the sci vessels to do the defence matrix. The medics are for blinding any detector that might come rushing in and to healthe ghosts if they get attacked. Make sure you upgrade ALL abilities for ghosts (lockdown optional), Science vessels, Battle cruisers (Colossus reactors optional), and the medics. This will work good if you work very fast. It'll require some "Skillz" in micromanagement but you should be able to pull it off. This doesn't require that much money and I've tried it on temple and it works very well. After 2 nukes hit the key buildings, he/she probably wont have that much money to rebuild them. You should've made a good attack force after you have nuked and drop/fly them over to thier base, Also geting a 3rd ghost to nuke where his/her units are station are also usefull.

CreepColony's Opinion: Watch out for overlords, observers, science vessels, and comsat stations.